Perforating the nuclear boundary – how nuclear pore complexes assemble
نویسندگان
چکیده
منابع مشابه
Perforating the nuclear boundary - how nuclear pore complexes assemble.
The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded within the nuclear envelope, and control molecular exchange between the cytoplasm and nucleoplasm. In this Commentary, we discuss the biogen...
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What do they look like? A picture is worth twice the length of this article (Figure 1). All eukaryotes have these impressive structures: vertebrates have the Cadillac model (~125 MDa) and yeast a sportier version (~50 MDa). In spite of their immense size, these structures are made of a relatively small number of proteins — about 30 — the so-called nucleoporins or nups. Defining an NPC ‘interact...
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In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.
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NPCs are the sole sites of exchange between the nucleus and cytoplasm. A large family of transport factors carry cargo between the nucleus and cytoplasm through the NPC. The NPC is a huge symmetric octagonal structure comprised of dozens of NUPs. NUPs make many contacts with surrounding structures, including the NE, the cytoplasm and nuclear interior. A subset of NUPs contain repeated peptide m...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2016
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.194753